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M9490313.TXT
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1994-09-19
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Document 0313
DOCN M9490313
TI Prevalence of human T cell lymphotropic virus type II in American Indian
populations of the southwestern United States.
DT 9411
AU Hjelle B; Khabbaz RF; Conway GA; North C; Green D; Kaplan JE; Department
of Pathology, University of New Mexico School of; Medicine, Albuquerque.
SO Am J Trop Med Hyg. 1994 Jul;51(1):11-5. Unique Identifier : AIDSLINE
MED/94337917
AB We investigated the seroprevalence of human T cell lymphotropic virus
type II (HTLV-II) using a screening enzyme-linked immunosorbent assay
(ELISA) and immunoblot confirmation among the predominant tribes (Pueblo
and Athapaskan) served by two large Indian Health Service facilities in
New Mexico. Among persons being treated for sexually transmitted
diseases, eight (3.2%) of 250 were seropositive for HTLV II, compared
with eight (2.1%) of 385 women attending prenatal clinics. In a survey
of unselected patients at one of the facilities, 15 (3.4%) of 446 were
seropositive. Of 31 seropositive subjects, 25 were infected with HTLV-II
and six infections could not be typed. Sera from nine (29%) of the 31
infected subjects had absorbance values less than the manufacturer's
cutoff in the ELISA. Both Pueblo and Athapaskan groups had similar
overall seroprevalences, but women tended to have a slightly higher
seroprevalence than men, and seroprevalence tended to increase with age.
These data show that HTLV-II infection is present among diverse groups
of American Indians in the southwestern United States. Present ELISA
screening tests, such as those used in this study, lack sensitivity to
HTLV-II infection unless a reduced absorbance cutoff is used.
DE Adolescence Adult Aged Blotting, Western Child Child, Preschool
Enzyme-Linked Immunosorbent Assay Female Human HTLV-II
Antibodies/*BLOOD HTLV-II Infections/COMPLICATIONS/*ETHNOLOGY
*Indians, North American Male Middle Age Pregnancy Pregnancy
Complications, Infectious/*ETHNOLOGY Prevalence Retrospective Studies
Southwestern United States/EPIDEMIOLOGY Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).